🇷🇺 Russian Emergencies Minister Yevgeny Zinichev died during a training exercise in the Arctic on Wednesday, RIA news agency cited the ministry as saying. -Reuters
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Forwarded from GLOBAL NEWS NEXUS
🇷🇺⚡🇺🇸 The FSB has confirmed CNN's reports of the CIA's involvement in an operation to detain 33 Russians in Minsk in 2020.
According to the intelligence service, the Russians were lured to Belarus by the SBU and the intelligence of the Ukrainian Ministry of Defense under the leadership of the CIA, it was a planned kidnapping, and the main purpose of the operation was to break relations between Russia and Belarus.
“Everything that we see from the Ukrainian special services, other than acts of state terrorism, the instrument of which they are, we cannot assess,” the FSB said.
According to the intelligence service, the Russians were lured to Belarus by the SBU and the intelligence of the Ukrainian Ministry of Defense under the leadership of the CIA, it was a planned kidnapping, and the main purpose of the operation was to break relations between Russia and Belarus.
“Everything that we see from the Ukrainian special services, other than acts of state terrorism, the instrument of which they are, we cannot assess,” the FSB said.
„This week, Wageningen University and Research in the Netherlands announced that it will allow non-profit organizations to use its CRISPR–Cas9 gene-editing technology for free, for non-commercial applications in food and agriculture. It’s an important development, and another step towards making a technology with untapped potential more accessible — especially for researchers in low- and middle-income countries.
Wageningen is one of a clutch of research institutions globally that hold patents on CRISPR, a technique that enables precise changes to be made to genomes, at specific locations. Other institutions — including the Broad Institute in Cambridge, Massachusetts, and the University of California, Berkeley, which have some of the largest portfolios of patents on the subject — also provide CRISPR tools and some intellectual property (IP) for free for non-profit use.
The field is snowballing. The US Patent and Trademark Office alone has around 6,000 CRISPR patents or patent applications, with 200 being added every month, mostly from China and the United States.“
@auraxchan
https://www.nature.com/articles/d41586-021-02420-x
Wageningen is one of a clutch of research institutions globally that hold patents on CRISPR, a technique that enables precise changes to be made to genomes, at specific locations. Other institutions — including the Broad Institute in Cambridge, Massachusetts, and the University of California, Berkeley, which have some of the largest portfolios of patents on the subject — also provide CRISPR tools and some intellectual property (IP) for free for non-profit use.
The field is snowballing. The US Patent and Trademark Office alone has around 6,000 CRISPR patents or patent applications, with 200 being added every month, mostly from China and the United States.“
@auraxchan
https://www.nature.com/articles/d41586-021-02420-x
Nature
License CRISPR patents for free to share gene editing globally
Nature - Universities hold the majority of CRISPR patents. They are in a strong position to ensure that the technology is widely shared for education and research.
Forwarded from Aurax
The gene editing system CRISPR-Cas9 makes breaks in DNA strands that are repaired by cells—a process that can be hard to control, resulting in unwanted genetic changes. Researchers at the Massachusetts Institute of Technology and the University of California, San Francisco (UCSF) designed an alternative technology that changes gene expression without damaging DNA, and they believe it could be useful for both research and drug development.
The researchers used their system, dubbed CRISPRoff and CRISPRon, to induce pluripotent stem cells to transform into neurons. They also used it to silence the gene that makes the protein Tau, which has been implicated in Alzheimer’s disease. They described their research in the journal Cell.
The MIT and UCSF researchers started by creating a machine made of a protein and small RNAs that guided it to specific spots on strands of DNA. The machine adds “methyl groups” to genes to silence their expression. The technology can also reverse the process, turning the genes back on by removing the methyl groups.
https://www.fiercebiotech.com/research/mit-and-ucsf-researchers-create-crispr-off-switch-controls-gene-expression-without
The researchers used their system, dubbed CRISPRoff and CRISPRon, to induce pluripotent stem cells to transform into neurons. They also used it to silence the gene that makes the protein Tau, which has been implicated in Alzheimer’s disease. They described their research in the journal Cell.
The MIT and UCSF researchers started by creating a machine made of a protein and small RNAs that guided it to specific spots on strands of DNA. The machine adds “methyl groups” to genes to silence their expression. The technology can also reverse the process, turning the genes back on by removing the methyl groups.
https://www.fiercebiotech.com/research/mit-and-ucsf-researchers-create-crispr-off-switch-controls-gene-expression-without
Fierce Biotech
MIT and UCSF researchers create CRISPR 'on-off switch' that controls gene expression without changing DNA
The gene editing system CRISPR-Cas9 makes breaks in DNA strands that are repaired by cells—a process that can be hard to control, resulting in unwanted genetic changes. | Researchers at the Massachusetts Institute of Technology and the University of California…
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GEN - Genetic Engineering and Biotechnology News
Parallel Genome Editing in Microscopic Worms Maps Regulatory Genomic Elements to Physiology
A group of systems biologists in Berlin have developed parallel genome editing in tiny worms to produce diverse indel mutations in regulatory elements in genomic DNA and a powerful software package, crispr-DART, to analyze the indel mutations following targeted…
Forwarded from Aurax
„When a single gene in a cell is turned on or off, its resulting presence or absence can affect the function and survival of the cell. In a new study appearing May 24 in Nature Neuroscience, UCSF researchers have successfully catalogued this effect in the human neuron by separately toggling each of the 20,000 genes in the human genome.
In doing so, they've created a technique that can be employed for many different cell types, as well as a database where other researchers using the new technique can contribute similar knowledge, creating a picture of gene function in disease across the entire spectrum of human cells.
"This is the key next step in uncovering the mechanisms behind disease genes," said Martin Kampmann, PhD, associate professor, Institute for Neurodegenerative Diseases and the UCSF Weill Institute for Neurosciences, noting that the work leverages recent advances in gene sequencing, stem cell technology, and CRISPR.“
https://www.eurekalert.org/pub_releases/2021-05/uoc--fcs051921.php
In doing so, they've created a technique that can be employed for many different cell types, as well as a database where other researchers using the new technique can contribute similar knowledge, creating a picture of gene function in disease across the entire spectrum of human cells.
"This is the key next step in uncovering the mechanisms behind disease genes," said Martin Kampmann, PhD, associate professor, Institute for Neurodegenerative Diseases and the UCSF Weill Institute for Neurosciences, noting that the work leverages recent advances in gene sequencing, stem cell technology, and CRISPR.“
https://www.eurekalert.org/pub_releases/2021-05/uoc--fcs051921.php
EurekAlert!
Full-genome CRISPR screen reveals surprising ways neurons survive oxidative stress
When a single gene in a cell is turned on or off, its resulting presence or absence can affect the function and survival of the cell. In a new study appearing May 24 in Nature Neuroscience, UCSF researchers have successfully catalogued this effect in the…
Forwarded from Aurax
A recent study by researchers from Sweden and the United Kingdom shows that CRISPR/Cas9-based genomic engineering can prompt unwanted on-target effects, and highlights the complexity of human DNA repair mechanisms in the presence of the powerful prokaryotic Cas9 nuclease.
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https://www.biorxiv.org/content/10.1101/2021.07.01.450727v1
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https://www.biorxiv.org/content/10.1101/2021.07.01.450727v1
bioRxiv
CRISPR/Cas9 deletions induce adverse on-target genomic effects leading to functional DNA in human cells
The CRISPR/Cas9 system is widely used to permanently delete genomic regions by inducing double-strand breaks via dual guide RNAs. However, consequences of Cas9 deletion events have not been fully investigated. To characterize Cas9-induced genotypic abnormalities…
Forwarded from Arms Watch (Dilyana)
Media is too big
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Skripals blood samples could have been manipulated, chain of custody broken, newly disclosed information obtained from the UK Defense ministry reveals http://dilyana.bg/uk-defense-ministry-document-reveals-skripals-blood-samples-could-have-been-manipulated/
Who said Taliban is changed?! They are still some of the most dangerous barbaric creatures in the world. See what they have done to the instruments of National Music Institute of Afghanistan at Kabul. Now, Music is fully banned in Afghanistan under Sharia law of Taliban.
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@auraxchan
🇩🇪At 6am today morning a men in Hamburg was raided by local police officials. They searched for his PC/Handy. It’s pretty likely that the order for the raid came on special wish.
Background: the men wrote under a social media post of hamburgs interior senator (Andy grote)
„one time beeing responsible for the continuing of the pandemic. you’re such a di*k“
Daily covid insanity.
@auraxchan
Background: the men wrote under a social media post of hamburgs interior senator (Andy grote)
„one time beeing responsible for the continuing of the pandemic. you’re such a di*k“
Daily covid insanity.
@auraxchan
Elon Musk Mocks Jeff Bezos' Attempt to Develop Immortality Tech
https://futurism.com/elon-musk-mocks-jeff-bezos-immortality-tech/amp
@auraxchan
https://futurism.com/elon-musk-mocks-jeff-bezos-immortality-tech/amp
@auraxchan
Former Afghan President Ghani released a Statement.
It’s shared with „liar“ from tolonews reporters.
@auraxchan
It’s shared with „liar“ from tolonews reporters.
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North Korea 🇰🇵 will hold a military parade overnight.
Several key-routes inside Pyongyang are closed and heavily secured by military/police officials.
@auraxchan
Several key-routes inside Pyongyang are closed and heavily secured by military/police officials.
@auraxchan